Jacqueline T Hecht Selected Research

Pseudoachondroplasia

8/2021	Joint Degeneration in a Mouse Model of Pseudoachondroplasia: ER Stress, Inflammation, and Block of Autophagy.
3/2021	Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy.
1/2019	Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies.
9/2017	Novel therapeutic interventions for pseudoachondroplasia.
1/2017	Antisense Reduction of Mutant COMP Reduces Growth Plate Chondrocyte Pathology.
11/2015	Pseudoachondroplasia and painful sequelae.
7/2015	Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia.
7/2014	Pseudoachondroplasia/COMP - translating from the bench to the bedside.
1/2014	Chondrocyte-specific pathology during skeletal growth and therapeutics in a murine model of pseudoachondroplasia.
2/2012	D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.

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Jacqueline T Hecht Research Topics

Disease

23	Pseudoachondroplasia 08/2021 - 03/2002
8	Cleft Lip (Harelip) 10/2018 - 09/2005
7	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 04/2010 - 03/2002
6	Clubfoot (Talipes Equinovarus) 01/2022 - 12/2009
6	Inflammation (Inflammations) 03/2021 - 01/2014
3	Achondroplasia 01/2022 - 01/2014
3	Osteoarthritis 01/2021 - 06/2004
2	Cleft Palate (Palate, Cleft) 10/2018 - 07/2011
2	Osteochondroma (Osteocartilaginous Exostosis) 03/2015 - 03/2013
2	Exostoses 06/2005 - 09/2002
1	Dental Caries (Decay, Dental) 01/2021
1	Loeys-Dietz Syndrome 11/2020
1	Chondrosarcoma 01/2019
1	Tuberous Sclerosis 1 01/2019
1	Idiopathic Pulmonary Fibrosis 10/2018
1	Otitis 01/2017
1	Type 2 Diabetes Mellitus (MODY) 03/2015
1	Chondroma (Enchondroma) 03/2013
1	Multiple Hereditary Exostoses (Hereditary Multiple Exostoses) 03/2013
1	Contracture 01/2013
1	Arthrogryposis 01/2013
1	Fibrochondrogenesis 02/2012
1	Necrosis 02/2012
1	Neural Tube Defects (Exencephaly) 01/2011
1	Congenital Abnormalities (Deformity) 01/2011
1	Fever (Fevers) 03/2010
1	Zlotogora-Ogur syndrome 10/2009
1	Van der Woude syndrome 09/2005
1	Genetic Translocation (Chromosomal Translocation) 02/2004

Drug/Important Bio-Agent (IBA)

17	Cartilage Oligomeric Matrix ProteinIBA 08/2021 - 03/2002
11	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2002
6	Collagen Type IXIBA 06/2008 - 06/2004
3	Matrix Metalloproteinases (MMPs)IBA 08/2021 - 02/2004
3	Messenger RNA (mRNA)IBA 01/2019 - 04/2009
3	Extracellular Matrix ProteinsIBA 07/2014 - 03/2002
3	DNA (Deoxyribonucleic Acid)IBA 05/2014 - 09/2002
3	Glycoproteins (Glycoprotein)IBA 04/2010 - 04/2006
2	ResveratrolIBA 08/2021 - 01/2021
2	Mechanistic Target of Rapamycin Complex 1IBA 03/2021 - 01/2019
2	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2021 - 01/2014
2	Biological ProductsIBA 01/2021 - 12/2009
2	Proteoglycans (Proteoglycan)IBA 01/2021 - 06/2005
2	Cysteine (L-Cysteine)FDA Link 10/2018 - 07/2011
2	AntioxidantsIBA 01/2018 - 07/2015
2	CateninsIBA 03/2015 - 03/2013
2	Contractile ProteinsIBA 01/2013 - 09/2011
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2011 - 01/2011
2	NectinsIBA 10/2009 - 07/2009
1	Codon (Codons)IBA 01/2022
1	FilaminsIBA 01/2022
1	EnzymesIBA 08/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Transforming Growth Factor-beta Type I ReceptorIBA 11/2020
1	Transforming Growth Factor-beta Type II ReceptorIBA 11/2020
1	Transforming Growth Factor beta3 (TGF beta 3)IBA 11/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	TOR Serine-Threonine KinasesIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 10/2018
1	A-factor (Streptomyces)IBA 01/2017
1	Antisense OligonucleotidesIBA 01/2017
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 07/2015
1	Apoptosis Inducing FactorIBA 02/2012
1	CaspasesIBA 02/2012
1	Collagen Type XIIBA 02/2012
1	XenobioticsIBA 01/2011
1	AntipyreticsIBA 03/2010
1	Nonsense Codon (Nonsense Mutation)IBA 10/2009
1	mouse Comp proteinIBA 10/2009
1	Matrilin ProteinsIBA 01/2007
1	Complement System Proteins (Complement)IBA 04/2006
1	Protein Disulfide-IsomerasesIBA 03/2006
1	Interferon Regulatory FactorsIBA 09/2005
1	perlecanIBA 06/2005
1	Heparitin Sulfate (Heparan Sulfate)IBA 06/2005
1	CalciumIBA 01/2005
1	Collagen Type II (Type II Collagen)IBA 01/2005
1	Transcription Factors (Transcription Factor)IBA 02/2004
1	Metalloproteases (Metalloproteinases)IBA 02/2004
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/2004

Therapy/Procedure

5	Therapeutics 08/2021 - 01/2014
1	Middle Ear Ventilation (Tympanostomy) 01/2022
1	Tonsillectomy 01/2022
1	Adenoidectomy 01/2022
1	Replacement Arthroplasty 06/2004